Thermo Fisher Scientific Phospho-FGR (Tyr412) Polyclonal Antibody
FGR 단백질의 Tyr412 인산화 상태를 특이적으로 검출하는 폴리클로날 항체. Western blot 및 IHC(P) 실험에 적합하며, 사람, 생쥐, 랫트 시료에서 반응. 고순도 정제 및 안정한 PBS/glycerol 저장 용액 형태로 제공.
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FGR (Accession P09769), corresponding to amino acid residues around phosphorylated Tyr412. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817282 |
Product Specific Information
This antibody detects endogenous levels of FGR only when phosphorylated at Tyr412.
Target Information
FGR is a SRC-related kinase present in hematopoietic cells. It signals within multiple pathways, including the integrin pathway and downstream of chemokine and cytokine receptors.
This protein contains N-terminal sites for myristylation and palmitoylation, a PTK domain, and SH2 and SH3 domains that mediate protein-protein interactions with phosphotyrosine-containing and proline-rich motifs.
FGR localizes to plasma membrane ruffles and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway.
Infection with Epstein-Barr virus results in the overexpression of this protein.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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