Thermo Fisher Scientific CDC42BPB/MRCK beta Polyclonal Antibody
Rabbit polyclonal antibody targeting human MRCK beta (CDC42BPB). Validated for Western blot and immunoprecipitation. Antigen region 750–800 of MRCK beta. Supplied as liquid, 1 mg/mL, unconjugated. Recommended storage at 4°C, for research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 750 to 800 of human Serine/threonine-protein kinase MRCK beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Mouse and Rat
Target Information
CDC42BPB (MRCK beta) is a serine/threonine kinase involved in actin cytoskeleton assembly and organization.
MRCK-alpha and MRCK-beta (myotonic dystrophy kinase-related Cdc42-binding kinases) contain a cysteine-rich motif and a pleckstrin homology domain.
These kinases can phosphorylate nonmuscle Myosin light chain, influencing Actin-Myosin contractility.
MRCK-alpha activates LIM kinases downstream of Cdc42, leading to ADF/Cofilin inactivation and cytoskeletal reorganization.
It also contributes to neurite outgrowth mediated by Cdc42 and Rac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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