Thermo Fisher Scientific IL-1 beta Monoclonal Antibody (1400.24.17), Biotin
Mouse IL-1 beta 단백질을 표적으로 하는 Biotin 결합 단클론 항체로, ELISA와 Western blot 등 다양한 응용에 적합. 단백질 A로 정제된 고순도 제품이며, -20°C에서 안정적으로 보관 가능. 염증 관련 사이토카인 연구에 활용 가능.
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Thermo Fisher Scientific IL-1 beta Monoclonal Antibody (1400.24.17), Biotin
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (IHC) | - | 2 publications |
| ELISA | Assay-dependent | 8 publications |
| Neutralization (Neu) | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1400.24.17 |
| Immunogen | Recombinant mouse IL-1 beta |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 4% BSA |
| Contains | Proprietary preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_223603 |
Additional Formats
Product Specific Information
MM425BB targets IL-1 beta in ELISA and WB applications and shows reactivity with mouse samples.
The immunogen used is recombinant mouse IL-1 beta.
MM425BB detects IL-1 beta, which has a predicted molecular weight of approximately 17 kDa.
Target Information
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells.
It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol and is cleaved into the active 17 kDa form upon inflammasome activation.
IL-1 beta signals through IL-1RI and IL-1RII receptors, shared with IL-1 alpha, and its activity can be moderated by IL-1 Receptor Antagonist (IL-1RA).
It plays a key role in innate host defense and acute-phase responses, with elevated levels linked to chronic inflammatory conditions.
Neutralizing antibodies against IL-1 beta have potential therapeutic value.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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