Thermo Fisher Scientific IL-1 beta Monoclonal Antibody (1400.24.17), Biotin
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 재고 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
MM425BB | - | Thermo Fisher Scientific MM425BB IL-1 beta Monoclonal Antibody (1400.24.17), Biotin 250 ug pk | 재고문의 | pk | 717,000원 | - | 788,700원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Western Blot (WB)
Assay-dependent
Immunohistochemistry (IHC)
-
View 2 publications 2 publications
ELISA (ELISA)
Assay-dependent
View 8 publications 8 publications
Neutralization (Neu)
-
View 1 publication 1 publication
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Mouse / IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1400.24.17
Immunogen
Recombinant mouse IL-1 beta
Conjugate
Biotin Biotin Biotin
View additional formats
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS with 4% BSA
Contains
proprietary preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_223603
Product Specific Information
MM425BB targets IL-1 beta in ELISA, and WB applications and shows reactivity with mouse samples.
The MM425BB immunogen is recombinant mouse IL-1 beta.
MM425BB detects IL-1 beta which has a predicted molecular weight of approximately 17 kDa.
Target Information
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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