Thermo Fisher Scientific Human IRAK4 Synthetic Peptide
인간 IRAK4 단백질의 카복시 말단 아미노산 서열을 기반으로 한 합성 펩타이드. 폴리클로날 항체 PA5-20018의 블로킹 펩타이드로 사용 가능. Toll/IL-1 신호 경로 연구에 활용. 연구용으로만 사용.
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Thermo Fisher Scientific Human IRAK4 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to amino acids near the carboxy terminus of human IRAK-4.
PEP-0137 can be used as a blocking peptide with polyclonal antibody PA5-20018.
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1.
IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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