Thermo Fisher Scientific Human TLR2 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the amino terminus of human TLR2.
PEP-0139 can be used as a blocking peptide with polyclonal antibody PA5-20020.

Target Information

TLR2 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B.
TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively.
TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The various TLRs exhibit different patterns of expression.

TLR2 is expressed most abundantly in peripheral blood leukocytes and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. It aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediates cytokine production necessary for effective immunity.

Ten human homologs of TLRs (TLR1–10) have been described. TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, and in activated B-cells in germinal centers. CD14+ monocytes express the highest level of TLR2 followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells.

The expression of TLR2 on different cell types is regulated by immune response modifiers. LPS, GM-CSF, IL-1, and IL-10 upregulate TLR2, whereas IL-4, IFN-gamma, and TNF downregulate TLR2 expression in monocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.