Thermo Fisher Scientific Androgen Receptor Polyclonal Antibody
Thermo Fisher Scientific의 Androgen Receptor Polyclonal Antibody는 사람 AR 단백질을 대상으로 한 토끼 IgG 폴리클로날 항체로, WB에서 1:1,000 희석으로 검증되었습니다. 합성 펩타이드 면역원 기반, 항원 친화 크로마토그래피 정제, -20°C 보관 조건을 갖습니다. 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Ser215 of human androgen receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 40 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985722 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, the receptor translocates into the nucleus, dimerizes, and stimulates transcription of androgen-responsive genes.
AR signaling is crucial for development and function of male reproductive organs such as the prostate and epididymis, and also plays roles in muscle, hair follicles, and brain.
Abnormalities in AR signaling are associated with diseases including prostate cancer, Kennedy’s disease, and male infertility. Mutations cause complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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