Thermo Fisher Scientific Phospho-VASP (Ser239) Polyclonal Antibody

Applications and Tested Dilution

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding pSer239 of human VASP (UniProt ID: P50552-1).

Conjugate

Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage Buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol

Contains

No preservative

Storage Conditions

-20°C

Shipping Conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10979068

Product Specific Information

• It is not recommended to aliquot this antibody.
• This antibody is not cross-reactive with phosphorylated VASP homologues, such as Mena.

Target Information

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. These proteins contain an EVH1 N-terminal domain that binds proteins with E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. The mid-region includes a proline-rich domain that binds SH3 and WW domain-containing proteins, while the C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and plays a role in cell adhesion and motility, as well as in intracellular signaling regulating integrin-extracellular matrix interactions. VASP activity is regulated by cyclic nucleotide-dependent kinases PKA and PKG.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.