Thermo Fisher Scientific EAR2 Polyclonal Antibody
EAR2/NR2F6 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from N-terminal of human NR2F6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635238 |
Product Specific Information
This antibody detects endogenous levels of total EAR2 / NR2F6 protein.
Target Information
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements containing imperfect 5'-AGGTCA-3' direct or inverted repeats, recognized by other nuclear hormone receptors. Modulates hormonal responses and represses transcriptional activity of genes such as LHCGR, REN, and OXT. Regulates thyroid hormone receptor activity in a cell type-specific manner and inhibits NFATC transcription factor DNA binding. Acts as a transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells, potentially contributing to immune tolerance and autoimmunity. Plays a role in forebrain circadian clock development and is required early in the development of the locus coeruleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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