Thermo Fisher Scientific CD205 Chimeric Recombinant Rabbit Monoclonal Antibody (NLDC145)
CD205 단백질을 인식하는 재조합 토끼 단일클론 항체로, 마우스 DEC-205에 특이적입니다. Western blot, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합합니다. Protein A로 정제된 액상 형태이며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | NLDC145 |
| Immunogen | This antibody was raised by immunising Wistar rats with mouse lymph node stroma. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody is specific for murine DEC-205, a lectin endocytic receptor expressed at high levels by many dendritic cell subsets, where it mediates antigen uptake.
The epitope recognised by this antibody is trypsin-sensitive.
Target Information
CD205 (LY25, Lymphocyte Antigen 75) is an integral membrane glycoprotein involved in antigen uptake, trafficking, and presentation that improves the induction of antigen-specific T cell immunity.
CD205 is highly expressed by CD8+ dendritic cells (DCs) and also expressed at different levels by bone marrow Gr1+ cells, Langerhans cells, bone marrow-derived DCs (BMDC), and thymic epithelial cells.
CD205 acts as an endocytic receptor that directs captured antigens to the extracellular space towards a specialized antigen processing region.
Further, CD205 also prompts the reduced proliferation of B lymphocytes.
Diseases associated with CD205 dysfunction include pneumonic plague and lipid pneumonia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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