Thermo Fisher Scientific Basiliximab Chimeric Recombinant Mouse Monoclonal Antibody (Basiliximab)
Basiliximab은 인간 IL-2 수용체 α-사슬(CD25)에 특이적으로 결합하는 키메라 마우스 단클론 항체입니다. T세포 활성화를 억제하여 면역 반응을 조절하며, 다양한 면역학적 연구에 활용됩니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 어플리케이션에 적용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cynomolgus monkey, Human, Rhesus monkey |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Basiliximab |
| Immunogen | Basiliximab was prepared by immunizing BALB/c mice with CTC 16 cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
Basiliximab recognises the human IL-2R and binds to the epitope (116)ERIYHFV(122) within the extracellular domain of the CD25 subunit. Binding is abolished when two or more residues within the epitope are mutated. This epitope overlaps with the interaction site of CD25 and IL-2. CD25 is found in the high-affinity IL-2R (αβγc). T cells express CD25 only upon activation. IL-2 binding to IL-2R on T cells modulates proliferation and differentiation.
Target Information
Basiliximab is a recombinant chimeric (murine/human) monoclonal antibody (IgG1κ) that functions as an immunosuppressive agent. It specifically binds to and blocks the interleukin-2 receptor α-chain (IL-2Rα, also known as CD25 antigen) on the surface of activated T-lymphocytes.
It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell line genetically engineered to express plasmids containing the human heavy and light chain constant region genes and mouse heavy and light chain variable region genes encoding the RFT5 antibody that binds selectively to IL-2Rα.
Basiliximab binds with high affinity to the α-subunit (CD25) of the high-affinity IL-2 receptor, inhibiting IL-2 binding and T-cell activation, thereby preventing immune response against foreign kidney tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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