Thermo Fisher Scientific FGFR5 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.1 µg/mL

-

Immunohistochemistry (Frozen) (IHC (F))

5-15 µg/mL

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse FGF R5 beta Ala21-Pro374 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FGFR5,uniProtId:Q91V87-1,ncbiNodeId:10090,antigenRange:21-374,antigenLength:529,antigenImageFileName:PA5-47218_FGFR5_Q91V87-1_Goat.svg,antigenImageFileNamePDP:PA5-47218_FGFR5_Q91V87-1_Goat_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2606312

Product Specific Information

In Western blots, less than 5% cross-reactivity with recombinant human (rh) FGF R1 alpha (IIIb), recombinant mouse (rm) FGF R2 beta (IIIc), rmFGF R3 alpha (IIIb), rhFGF R3 alpha (IIIc), rhFGF R1 beta (IIIc), rmFGF R2 beta (IIIb), rhFGF R1 alpha (IIIc), rmFGF R2 alpha (IIIc), rhFGF R1 beta (IIIb), rmFGF R2 alpha (IIIb), rmFGF R2, and rmFGF R4 is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuro-ectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. A total of six members of the FGF receptor family have been identified and cloned. These include the Flg receptor or FGFR-1, the BEK receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. However, FGFR-5 lacks the cytoplasmic kinase domain. FGFR-5 is expressed in a broad range of tissues, including kidney, brain and lung, but it is preferentially expressed in pancreas, where it may play a role in the regulation of some pancreatic function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.