Thermo Fisher Scientific Calnexin Polyclonal Antibody
다양한 종에서 반응하는 Rabbit Polyclonal Calnexin 항체. Western blot에 적합하며 ER 단백질 접힘 연구에 사용. 고순도 액상 형태로 제공되며 -20°C 보관. 연구용으로만 사용 가능.
- 카탈로그번호
- 56414-100UL
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Calnexin Polyclonal Antibody
Applications
- Western Blot (WB): 1:5,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Chicken, Guinea pig, Hamster, Human, Mouse, Non-human primate, Sheep, Pig, Rabbit, Rat |
| Host / Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid synthetic peptide corresponding to canine calnexin conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Calnexin (also known as IP90, p88, p90) is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER). It functions as a molecular chaperone, assisting in the proper folding and assembly of polypeptides and multisubunit proteins. Calnexin interacts with MHC class I heavy chains, partial complexes of the T cell receptor, and B cell membrane immunoglobulin, but not with fully assembled receptor complexes. It retains incompletely or improperly folded proteins in the ER.
Soluble ER resident proteins often contain the Lys-Asp-Glu-Leu (KDEL) sequence for ER retention, while integral membrane proteins like calnexin lack this sequence but possess positively charged cytosolic residues ensuring retention. Calnexin consists of a large ER luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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