Thermo Fisher Scientific STAT2 Polyclonal Antibody
STAT2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, IP 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태입니다. Human STAT2에 반응하며 4°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 175 and 225 of Human Signal Transducer and Activator of Transcription 2 (STAT2, UniProt ID: P52630-3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
STAT2 belongs to the STAT protein family. Upon cytokine or growth factor stimulation, STAT proteins are phosphorylated by receptor-associated kinases, forming homo- or heterodimers that translocate to the nucleus and act as transcription activators.
In response to interferon (IFN), STAT2 forms a complex with STAT1 and p48 (ISGF3G), functioning as a transactivator without direct DNA-binding ability. STAT2 interacts with transcription adaptor P300/CBP (EP300/CREBBP), potentially contributing to adenovirus-mediated inhibition of IFN-alpha response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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