Thermo Fisher Scientific ETO Polyclonal Antibody
Rabbit polyclonal antibody against human ETO (RUNX1T1) protein. Validated for WB and IP applications. Recognizes region 554–604 of RUNX1T1. Supplied as liquid, 1 mg/mL, stored at 4°C. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,500 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 554 and 604 of human Eight Twenty One (RUNX1T1) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
RUNX1T1 is a putative zinc finger transcription factor and oncoprotein.
In acute myeloid leukemia (particularly M2 subtype), the t(8;21)(q22;q22) translocation is one of the most frequent abnormalities.
This translocation produces a chimeric gene combining the 5′ region of RUNX1 with the 3′ region of RUNX1T1.
The resulting chimeric protein associates with the nuclear corepressor/histone deacetylase complex, blocking hematopoietic differentiation.
Several transcript variants encoding multiple isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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