Thermo Fisher Scientific Myocilin Polyclonal Antibody, Biotin
Myocilin 단백질을 표적하는 Biotin 결합 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. 인간 및 설치류 등 여러 종에 반응. Affinity chromatography로 정제된 고품질 항체로 연구용으로만 사용 가능.
- 카탈로그번호
- MYO112-BIOTIN
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to unique amino acid sequence on Myocilin protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Myocilin is an extracellular protein expressed in the eye, including the retina, trabecular meshwork, and ciliary body. It can form homomultimers in vivo and associate with extracellular matrix components via interactions with the Hep II domain of FibroPVRL1. Myocilin also interacts with the myosin regulatory light chain, suggesting a role in the actomyosin system and linking it to the functional status of the trabecular meshwork (TM), which regulates intraocular pressure (IOP). Dysfunction of the TM may lead to elevated IOP and development of glaucoma, a major cause of blindness.
The MYOC gene (also designated TIGR) maps to the GLC1A locus on chromosome 1q24.3 and is associated with mutations linked to primary open-angle glaucoma (POAG).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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