Thermo Fisher Scientific Phospho-ATR (Ser428) Polyclonal Antibody
Human ATR 단백질의 Ser428 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. IHC(P)에서 1:50~1:100 희석으로 사용 가능. DNA 손상 반응 및 세포 주기 조절 연구에 적합. 항원 친화 크로마토그래피로 정제된 고품질 시약.
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Applications
Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of serine 428 (G-I-S(p)-P-K) derived from Human ATR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2607921 |
Target Information
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress.
It phosphorylates and activates several proteins involved in the inhibition of DNA replication and mitosis, and promotes DNA repair, recombination, and apoptosis.
This protein is also important for fragile site stability and centrosome duplication.
Defects in this gene are a cause of Seckel syndrome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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