Thermo Fisher Scientific CD18 Monoclonal Antibody (MEM-48), FITC

Applications

• Flow Cytometry (Flow): 20 µL / 1×10⁶ cells

Product Specifications

Available Formats

• Unconjugated (MA1-19007)
• APC (MA1-19456)
• Biotin (MA1-19492)
• PE (MA1-19632)
• Custom conjugation available upon request

Product Specific Information

This antibody recognizes an extracellular epitope involving residues 534–546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta2 subunit; beta2 integrin). CD18 is a 90–95 kDa type I transmembrane protein expressed on all leukocytes.
It does not cross-react with canine.

Target Information

CD18 (integrin beta 2 subunit) is a 90 kDa type I transmembrane protein expressed on all leukocytes. It forms heterodimers with CD11 molecules (CD11a–d) to constitute leukocyte (beta2) integrins:

• αLβ2 (CD11a/CD18, LFA-1)
• αMβ2 (CD11b/CD18, Mac-1, CR3)
• αXβ2 (CD11c/CD18)
• αDβ2 (CD11d/CD18)

These integrins are essential for leukocyte adhesion and migration. Absence or reduction of CD18 expression can lead to leukocyte adhesion deficiency type I (LAD1) or psoriasiform skin disease. CD18 also mediates leukotoxin-induced cytolysis by Mannheimia haemolytica. Two transcript variants encoding CD18 protein have been identified.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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