Thermo Fisher Scientific CD18 Monoclonal Antibody (MEM-48), FITC
인간 CD18 항원을 인식하는 Mouse IgG1 단클론 항체로, FITC로 표지되어 있습니다. Flow Cytometry에 적합하며, 498/517 nm의 여기/방출 파장을 가집니다. PBS(pH 7.4)와 0.2% BSA, 15mM sodium azide 용액에 보관됩니다.
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Applications
- Flow Cytometry (Flow): 20 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-48 |
| Immunogen | Leucocytes from a patient suffering from a LGL type leukaemia |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1071394 |
Available Formats
- Unconjugated (MA1-19007)
- APC (MA1-19456)
- Biotin (MA1-19492)
- PE (MA1-19632)
- Custom conjugation available upon request
Product Specific Information
This antibody recognizes an extracellular epitope involving residues 534–546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta2 subunit; beta2 integrin). CD18 is a 90–95 kDa type I transmembrane protein expressed on all leukocytes.
It does not cross-react with canine.
Target Information
CD18 (integrin beta 2 subunit) is a 90 kDa type I transmembrane protein expressed on all leukocytes. It forms heterodimers with CD11 molecules (CD11a–d) to constitute leukocyte (beta2) integrins:
- αLβ2 (CD11a/CD18, LFA-1)
- αMβ2 (CD11b/CD18, Mac-1, CR3)
- αXβ2 (CD11c/CD18)
- αDβ2 (CD11d/CD18)
These integrins are essential for leukocyte adhesion and migration. Absence or reduction of CD18 expression can lead to leukocyte adhesion deficiency type I (LAD1) or psoriasiform skin disease. CD18 also mediates leukotoxin-induced cytolysis by Mannheimia haemolytica. Two transcript variants encoding CD18 protein have been identified.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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