Thermo Fisher Scientific ITGB1 Monoclonal Antibody (MEM-101A), FITC

Applications and Tested Dilution

Publications:

• Flow Cytometry: View 2 publications
• Miscellaneous PubMed: View 1 publication

Product Specifications

Available Formats:

• Unconjugated
• APC
• Biotin
• PE
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular epitope of CD29 (integrin beta1 chain), a 130 kDa single-chain type I glycoprotein expressed as a heterodimer (non-covalently associated with integrin alpha subunits 1–6).
CD29 is broadly expressed on hematopoietic and non-hematopoietic cells including leukocytes, platelets, fibroblasts, endothelial cells, epithelial cells, and mast cells.
This antibody does not cross-react with mouse.

Target Information

ITGB1 (Integrin Subunit Beta 1, CD29) is a 110 kDa cell surface glycoprotein widely expressed by various cell types, including all leukocytes.
ITGB1 forms non-covalent heterodimers with at least six different alpha chains (α1–α6), determining the binding properties of β1 (VLA) integrins.
It functions as a cell adhesion molecule on platelets and as the common β subunit of very late activation antigens (VLAs).

Decreased ITGB1 expression correlates with multidrug resistance in tumor cells. It is up-regulated in leukocytes during migration and plays a key role in immune cell trafficking from blood to tissues.
ITGB1 also regulates tissue damage and disease symptoms in inflammatory bowel disease. Through an ITGB1-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1β.

There are two major isoforms of integrin β1: β1A and β1D, which differ by 13 amino acids. β1A is present in all tissues except cardiac and skeletal muscle, where β1D is expressed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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