Thermo Fisher Scientific ITGB1 Monoclonal Antibody (MEM-101A), FITC
CD29(ITGB1) 인식 단일클론 항체로, FITC 형광 표지되어 유세포분석에 적합. 인간, 개, 돼지 반응성. 마우스 비교반응 없음. 액상 형태로 PBS 완충액에 0.2% BSA 포함, 4°C 암소 보관. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 20 µL / 1×10⁶ cells |
Publications:
- Flow Cytometry: View 2 publications
- Miscellaneous PubMed: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Pig |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-101A |
| Immunogen | Burkitt’s lymphoma cell line Raji |
| Conjugate | FITC (Fluorescein) |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1075425 |
Available Formats:
Product Specific Information
This antibody reacts with an extracellular epitope of CD29 (integrin beta1 chain), a 130 kDa single-chain type I glycoprotein expressed as a heterodimer (non-covalently associated with integrin alpha subunits 1–6).
CD29 is broadly expressed on hematopoietic and non-hematopoietic cells including leukocytes, platelets, fibroblasts, endothelial cells, epithelial cells, and mast cells.
This antibody does not cross-react with mouse.
Target Information
ITGB1 (Integrin Subunit Beta 1, CD29) is a 110 kDa cell surface glycoprotein widely expressed by various cell types, including all leukocytes.
ITGB1 forms non-covalent heterodimers with at least six different alpha chains (α1–α6), determining the binding properties of β1 (VLA) integrins.
It functions as a cell adhesion molecule on platelets and as the common β subunit of very late activation antigens (VLAs).
Decreased ITGB1 expression correlates with multidrug resistance in tumor cells. It is up-regulated in leukocytes during migration and plays a key role in immune cell trafficking from blood to tissues.
ITGB1 also regulates tissue damage and disease symptoms in inflammatory bowel disease. Through an ITGB1-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1β.
There are two major isoforms of integrin β1: β1A and β1D, which differ by 13 amino acids. β1A is present in all tissues except cardiac and skeletal muscle, where β1D is expressed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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