Thermo Fisher Scientific CD16 Monoclonal Antibody (MEM-154), FITC

Applications

• Flow Cytometry (Flow): 20 µL reagent / 100 µL or 10⁶ cells
• View 1 publication

Product Specifications

Additional Formats

• Unconjugated
• Biotin
• PE
• Request custom conjugation

Product Specific Information

This antibody reacts with CD16⁺ granulocytes and can be used for mapping CD16-158V/F polymorphism on NK cells, as it requires the presence of valine (V) at amino acid position 158.

Target Information

CD16 encodes a receptor that recognizes the Fc portion of immunoglobulin G (IgG) and is involved in the clearance of immune complexes, antibody-dependent cellular cytotoxicity (ADCC), and modulation of viral infection responses.
The FCGR3A gene shares high similarity with FCGR3B, located nearby on chromosome 1.

• FCGR3A: Expressed on NK cells, membrane-anchored via a transmembrane peptide
• FCGR3B: Expressed on polymorphonuclear neutrophils (PMN), anchored via a phosphatidylinositol (PI) linkage

Mutations in FCGR3A are associated with:

• Immunodeficiency 20
• Susceptibility to recurrent viral infections
• Systemic lupus erythematosus
• Alloimmune neonatal neutropenia

Alternatively spliced transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지