Thermo Fisher Scientific Phospho-c-Myc (Thr58) Polyclonal Antibody
인간 c-Myc 단백질 Thr58 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, IP 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제된 고순도 제품. 세포 증식 및 종양 연구용에 적합.
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Thermo Fisher Scientific Phospho-c-Myc (Thr58) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunoprecipitation (IP) | 1:50–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human Myc around the phosphorylation site of Threonine 58 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553655 |
Product Specific Information
- Detects endogenous protein at molecular weights of 49, 57, and 65 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a key role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with cell proliferation and regulation.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression induces apoptosis in multiple cell types.
Amplification of the c-Myc gene has been found in lung, breast, and colon carcinomas, while N-Myc amplification is common in neuroblastomas.
Translocations involving the c-Myc locus are characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative diseases.
Aberrant c-Myc expression is observed in tumors of various origins including colorectal, gastric, hepatic, ovarian, and hematopoietic neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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