Thermo Fisher Scientific Phospho-c-Myc (Thr58) Polyclonal Antibody

Thermo Fisher Scientific Phospho-c-Myc (Thr58) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Detects endogenous protein at molecular weights of 49, 57, and 65 kDa.
• Purity is >95% by SDS-PAGE.

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a key role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with cell proliferation and regulation.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression induces apoptosis in multiple cell types.
Amplification of the c-Myc gene has been found in lung, breast, and colon carcinomas, while N-Myc amplification is common in neuroblastomas.
Translocations involving the c-Myc locus are characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative diseases.
Aberrant c-Myc expression is observed in tumors of various origins including colorectal, gastric, hepatic, ovarian, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.