Thermo Fisher Scientific SIRP beta/gamma Chimeric Recombinant Rabbit Monoclonal Antibody (OX117)
인간 SIRP-beta 및 SIRP-gamma에 특이적으로 결합하는 재조합 토끼 단클론 항체입니다. Flow Cytometry, ELISA, Immunoprecipitation 등에 사용 가능하며 HEK293 발현 시스템에서 생산되었습니다. 단백질 A 정제, 액상 형태로 제공되며 장기 보관 시 -20°C에서 보관합니다.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Flow Cytometry (Flow) | 1 µg/mL | |
| ELISA (ELISA) | Assay-dependent | |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | OX117 |
| Immunogen | Recombinant human SIRPgamma:CD4 fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074404 |
Product Specific Information
Specificity: This antibody binds to human SIRP-beta and gamma.
Target Information
SIRP beta and SIRP gamma are members of the signal regulatory protein (SIRP) family, transmembrane receptors expressed on immune and neuronal cells. They regulate cellular signaling pathways involved in immune responses, cell adhesion, and phagocytosis. These proteins interact with SHP-1, a protein tyrosine phosphatase that negatively regulates immune cell activation, promoting immune tolerance. Additionally, SIRP beta and gamma are implicated in neuronal signaling and synaptic plasticity, contributing to synapse formation and maintenance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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