Thermo Fisher Scientific SIRP beta/gamma Recombinant Mouse Monoclonal Antibody (OX117)
인간 SIRP-beta 및 SIRP-gamma 단백질을 인식하는 재조합 마우스 단클론 항체입니다. Flow Cytometry, ELISA, Immunoprecipitation에 사용 가능합니다. HEK293 세포에서 발현되며 Protein A로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
ELISA (ELISA)
- Tested Dilution: Assay-dependent
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | OX117 |
| Immunogen | Recombinant human SIRPgamma:CD4 fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074403 |
Product Specific Information
- Specificity: This antibody binds to human SIRP-beta and SIRP-gamma.
Target Information
SIRP beta and SIRP gamma are members of the signal regulatory protein (SIRP) family. These transmembrane receptors are expressed on immune cells and neurons. They regulate cellular signaling pathways involved in immune responses, cell adhesion, and phagocytosis. Specifically, they interact with the protein tyrosine phosphatase SHP-1, a negative regulator of immune cell activation. By binding to SHP-1, SIRP beta and SIRP gamma inhibit immune cell activation and promote immune tolerance. Additionally, these proteins are implicated in neuronal signaling and synaptic plasticity, contributing to synapse formation and regulation of neuronal activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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