Thermo Fisher Scientific Heat Shock 27kDa Protein 1 Recombinant Mouse Monoclonal Antibody (rHSPB1/7298)
Recombinant mouse monoclonal antibody targeting HSP27 (HSPB1) for IHC applications. Validated in human samples with high specificity. Useful for studying stress response, protein folding, and cytoskeletal organization. Supplied as liquid, 200 µg/mL, st...
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rHSPB1/7298 |
| Immunogen | Recombinant human full-length HSP27 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: MCF-7 or HeLa cells
- Expression: ~50% of breast carcinomas are positive for HSP27, especially those that are ER and/or PgR positive
- Cellular Location: Cytoplasm and nucleus
Target Information
HSPB1 (heat shock protein beta-1 or HSP27) is a small heat shock protein that functions as a molecular chaperone, maintaining denatured proteins in a folding-competent state. It plays a crucial role in stress resistance and actin organization. Through its chaperone activity, HSP27 regulates phosphorylation and axonal transport of neurofilament proteins. Mutations in the HSPB1 gene can result in Charcot-Marie-Tooth disease type 2F and distal hereditary motor neuronopathy type 2B.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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