Thermo Fisher Scientific GRB2 Polyclonal Antibody
GRB2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot 및 Immunocytochemistry에 사용 가능. 인간 반응성, 액상 형태, 1 mg/mL 농도. 연구용으로만 사용.
- 카탈로그번호
- PA110033
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1–2 µg/mL
- Immunocytochemistry (ICC/IF): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to C-terminus of human Grb2 (amino acids 198–217) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154189 |
Product Specific Information
This antibody recognizes Grb2, a highly conserved approximately 26 kDa intracellular adaptor protein.
The immunogen has 100% identity between human, cow, rat, and mouse.
Western Blot: Reducing conditions.
Target Information
GRB2 protein contains one SH2 domain flanked by two SH3 domains.
In response to EGF, GRB2 binds through its SH3 domains to the guanine nucleotide exchange factor Sos.
The GRB2–Sos complex then associates with the EGF receptor, playing a critical role in activation of the p21 ras signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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