Thermo Fisher Scientific Phospho-Axl (Tyr702) Polyclonal Antibody
Phospho-Axl (Tyr702) 특이적 rabbit polyclonal antibody로, 인산화된 AXL 단백질을 검출. WB, IHC, ICC/IF 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 고순도 액상 형태로 -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AXL (Accession P30530), corresponding to amino acid residues around phosphorylated Tyr702 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817616 |
Product Specific Information
Antibody detects endogenous levels of AXL only when phosphorylated at Tyr702.
Target Information
AXL is a chronic myelogenous leukemia-associated oncogene also linked to colon cancer and melanoma. It encodes a receptor tyrosine kinase that mediates signal transduction from the extracellular matrix into the cytoplasm. AXL binds growth factors such as GAS6 and is involved in cell proliferation and phagocytosis of apoptotic cells. Mice lacking TAM receptors exhibit degenerative and autoimmune phenotypes. AXL may also function as an entry receptor for filoviruses and marks a specific dendritic cell subpopulation (Siglec 6+/Axl+). Its expression can be upregulated by TLR ligands, and soluble AXL levels may indicate inflammation or cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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