Thermo Fisher Scientific Phospho-Trf2 (Ser365) Polyclonal Antibody
TRF2 단백질의 Ser365 인산화 상태를 특이적으로 인식하는 폴리클로날 항체입니다. Western blot, IHC, ICC/IF에 사용 가능합니다. 인간 및 생쥐 시료에 반응하며, 고순도의 정제 항체로 안정적인 신호 검출이 가능합니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TERF2 (Accession Q15554), corresponding to amino acid residues around phosphorylated Ser365. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817612 |
Product Specific Information
This antibody detects endogenous levels of TRF2 only when phosphorylated at Ser365, a site historically referenced as Ser323.
Target Information
TRF2 is a ubiquitously expressed protein involved in the regulation of telomere length. It contains a Myb-related DNA-binding motif and binds to duplex TTAGGG repeats, localizing to all human telomeres in metaphase chromosomes. TRF2 helps maintain telomere structure and protects chromosome ends. Mutant forms of TRF2 have been linked to the prevention of cellular senescence, and inhibition of TRF2 can induce apoptosis in certain mammalian cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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