Thermo Fisher Scientific Phospho-Axl (Tyr698) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of AXL only when phosphorylated at Tyr698.

Target Information

AXL is a chronic myelogenous leukemia-associated oncogene also linked to colon cancer and melanoma. It encodes a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors such as the vitamin K-dependent protein GAS6. AXL is involved in cell proliferation and phagocytosis of apoptotic cells through TAM receptor pathways. Deficiency in TAM receptors can result in degenerative phenotypes and autoimmune-like conditions similar to systemic lupus erythematosus. AXL may also act as an entry receptor for filoviruses and serves as a marker for certain dendritic cell subsets. Its expression can be upregulated by TLR ligands like LPS or poly I:C. Soluble AXL, generated via proteolytic cleavage, may indicate inflammation or cancer when elevated in plasma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.