Thermo Fisher Scientific CD33 Monoclonal Antibody (WM-54)
인간 CD33 단백질을 검출하는 WM-54 클론의 마우스 단클론 항체로, Flow Cytometry에 사용 가능. Protein A로 정제된 액상형 항체이며 PBS 버퍼에 보존. 급성 골수성 백혈병 연구 등 CD33 관련 면역학 연구에 적합.
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Applications
- Flow Cytometry (Flow): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | WM-54 |
| Immunogen | Leukemic cells from a patient with Acute Myeloid Leukemia |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2291253 |
Product Specific Information
MA1-90498 detects CD33 from human samples.
Target Information
CD33 is a transmembrane protein belonging to the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine phosphatases SHP-1 and SHP-2, and is subject to ubiquitin-mediated receptor removal.
CD33 is expressed on cells of the myelomonocytic lineage, binds sialic acid residues in N- and O-glycans, and serves as a therapeutic target for acute myeloid leukemia. It is found on granulocyte and macrophage precursors in bone marrow, but not on pluripotent stem cells. CD33 is also expressed on peripheral monocytes and is a useful marker for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias.
Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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