Thermo Fisher Scientific SLUG Polyclonal Antibody
SLUG 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 실험에 적합하며, 인간 및 마우스 반응성. 고순도 항원 친화 크로마토그래피로 정제된 액상 형태로 안정적 보관 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:10,000
- Publications: References
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human SLUG |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.18 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792662 |
Product Specific Information
- Keep as concentrated solution.
- Predicted Reactivity: Mouse (99%), Rat (98%), Zebrafish (85%), Xenopus laevis (95%), Dog (100%), Pig (97%), Sheep (98%), Rhesus Monkey (100%), Bovine (99%)
- Positive Control: human Slug-transfected 293T cells, U87-MG, SK-N-SH, IMR32, SK-N-AS, NT2D1
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Slug is a member of the Snail family of C2H2-type zinc finger transcription factors. It is involved in epithelial-mesenchymal transitions and neural tube formation during vertebrate embryogenesis. Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug binds E-box regions of promoters and represses transcription of genes such as E-cadherin and Claudin-1. Its expression in breast, esophageal, and colorectal carcinomas has been correlated with poor prognosis. Additionally, Slug protects hemopoietic progenitor cells from radiation-induced apoptosis by repressing p53-mediated transcription of Puma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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