Thermo Fisher Scientific HIF-1 beta Polyclonal Antibody

Thermo Fisher Scientific HIF-1 beta Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (84%), Rat (82%), Pig (91%), Rabbit (86%), Sheep (91%), Bovine (92%), Guinea pig (92%).
• Positive Control: 293T, A431, HeLa, HepG2 (untreated), HepG2 (1% O₂ treatment for 24 hr).
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products.
Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease, and chronic obstructive pulmonary disease.
HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis through posttranslational modification by prolyl hydroxylation.
HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Under normoxic conditions, HIF-1 alpha is hydroxylated, polyubiquinated, and degraded in proteosomes. Under hypoxic conditions, hydroxylation is prevented, leading to increased transcriptional activity.
In contrast, HIF-1 beta remains stable under either condition.
Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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