Thermo Fisher Scientific HIF-1 beta Polyclonal Antibody
HIF-1 beta 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. Human 및 Mouse 반응성. 고순도 항원 친화 크로마토그래피 정제 제품으로, 액상 형태(1 mg/mL)로 제공되며 장기 보관 시 -20°C 권장.
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Thermo Fisher Scientific HIF-1 beta Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human HIF1 beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792661 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (84%), Rat (82%), Pig (91%), Rabbit (86%), Sheep (91%), Bovine (92%), Guinea pig (92%).
- Positive Control: 293T, A431, HeLa, HepG2 (untreated), HepG2 (1% O₂ treatment for 24 hr).
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products.
Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease, and chronic obstructive pulmonary disease.
HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis through posttranslational modification by prolyl hydroxylation.
HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Under normoxic conditions, HIF-1 alpha is hydroxylated, polyubiquinated, and degraded in proteosomes. Under hypoxic conditions, hydroxylation is prevented, leading to increased transcriptional activity.
In contrast, HIF-1 beta remains stable under either condition.
Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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