Thermo Fisher Scientific Ubiquitin-conjugating Enzyme E2C/UBCH10 Monoclonal Antibody (CPTC-UBE2C-1)
Human UBE2C 단백질을 인식하는 Mouse 모노클로날 항체로, IHC(P) 및 ELISA에 적합합니다. 단백질 A/G로 정제된 액상 형태이며, 보존제가 포함되지 않습니다. 세포주기 조절 및 암 연구용으로 활용됩니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CPTC-UBE2C-1 |
| Immunogen | Recombinant human full-length UBE2C protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is tested in direct ELISA.
- For Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
- For staining of formalin-fixed tissues, heat tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, then cool at room temperature for 20 min.
Target Information
This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression.
It accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, it catalyzes Lys-11- and Lys-48-linked polyubiquitination.
Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase controlling progression through mitosis. Initiates Lys-11-linked polyubiquitin chains on APC/C substrates, leading to their degradation by the proteasome and promoting mitotic exit.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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