Thermo Fisher Scientific Phospho-GSK3 alpha/beta (Ser21, Ser9) Monoclonal Antibody (K.857.1)
GSK3α/β의 Ser21 및 Ser9 인산화 상태를 검출하는 고특이성 단일클론 항체. Western blot과 면역침강에 적합하며 인간, 마우스, 랫 등 다양한 종에 반응. 액상 형태로 -20°C 보관, 연구용으로만 사용 가능.
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1000
Immunoprecipitation (IP)
- Tested Dilution: 1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | K.857.1 |
| Immunogen | Synthetic phosphopeptide corresponding to residues around pSer21 of human GSK-3α |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 9 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10982412 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Glycogen synthase kinase-3 (GSK3) is a protein kinase originally identified as a regulator of glycogen synthase, a key enzyme in glycogen metabolism. It is involved in regulation of various cellular functions including protein synthesis, cell proliferation, differentiation, microtubule dynamics, and apoptosis.
GSK3’s substrate specificity requires a pre-existing phosphoserine or phosphotyrosine four residues C-terminal to the phosphorylation site. Two isoforms exist — GSK3α and GSK3β — regulated by phosphorylation. Phosphorylation of GSK3β on Ser9 (Ser21 in GSK3α) by protein kinase B (PKB) inactivates the enzyme, mediating growth factor inhibition. Activation occurs via phosphorylation of Tyr216 (Tyr279 in GSK3α).
Activated GSK3β phosphorylates multiple cellular proteins including p53, c-Myc, c-Jun, HSF-1, and cyclin D1. It also phosphorylates tau protein at abnormal sites, contributing to Alzheimer’s disease progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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