Thermo Fisher Scientific CNGB3 Polyclonal Antibody
Rabbit polyclonal antibody against human CNGB3 protein. Suitable for IHC applications with dilution range 1:300–1:2,000. Lyophilized form for stable storage. Specific for CNGB3 involved in visual signal transduction. For research use only.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of human CNGB3 conjugated to a blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: CNGB3.
Target Information
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as a second messenger. This protein can be activated by cGMP, leading to opening of the cation channel and depolarization of rod photoreceptors. It induces flickering channel gating, weakens outward rectification in the presence of extracellular calcium, increases sensitivity for L-cis diltiazem, and enhances cAMP efficiency when coexpressed with CNGA3. CNGB3 is essential for generating light-evoked electrical responses in red-, green-, and blue-sensitive cones.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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