Thermo Fisher Scientific PDGFRB Monoclonal Antibody (OTI1D1), TrueMAB
PDGFRB 단백질을 인식하는 Mouse IgG1 단클론 항체로 Western blot과 Immunocytochemistry에 적합. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도로 사용 가능. 세포 성장 및 신호전달 연구용으로 최적화된 TrueMAB 제품.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D1 |
| Immunogen | Full length human recombinant protein of human PDGFRB (RNP_002600) produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
PDGFRB (Platelet-Derived Growth Factor Receptor Beta) is a receptor tyrosine kinase involved in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for mesenchymal cells. The receptor can form homodimers or heterodimers with PDGFRA, depending on the ligand.
The PDGFRB gene is located on chromosome 5, near the genes for GM-CSF and M-CSF receptor, and may be implicated in 5-q syndrome.
A translocation between chromosomes 5 and 12 fusing PDGFRB (CD140b) with ETV6 is associated with chronic myeloproliferative disorders featuring eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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