Thermo Fisher Scientific NCAM1 Monoclonal Antibody (OTI2D4), TrueMAB

Thermo Fisher Scientific NCAM1 Monoclonal Antibody (OTI2D4), TrueMAB

Applications and Tested Dilution

• Western Blot (WB): 1:4,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that functions as an adhesive molecule and is widely expressed in the nervous system. Isoforms range from 120–180 kDa.
CD56 is present on T cells and NK cells and plays roles in cell migration, axonal growth, pathfinding, and synaptic plasticity. Polysialic modification reduces CD56-mediated adhesion.
Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins.
CD56 is expressed on most neuroectodermal-derived cell lines, tissues, and neoplasms including retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma. It is also a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors.
Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)