Thermo Fisher Scientific VHL Monoclonal Antibody (OTI1E1), TrueMAB
Human VHL 단백질을 인식하는 Mouse monoclonal antibody로 Western blot 및 IHC(P) 검증됨. Lyophilized 형태로 제공되며, carrier-free 상태로 conjugation 실험에 적합. 고순도 affinity chromatography 정제 제품으로 연구용에만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:4,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E1 |
| Immunogen | Full length human recombinant protein of human VHL produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Von Hippel-Lindau (VHL) syndrome is a dominantly inherited familial cancer syndrome associated with various malignant and benign tumors.
Mutations in the VHL gene cause the syndrome. The encoded protein forms a complex with elongin B, elongin C, and cullin-2, functioning as a ubiquitin ligase E3.
It regulates degradation of hypoxia-inducible factor (HIF), a key transcription factor in oxygen-dependent gene expression.
POLR2G/RPB7 is also reported as a target.
Alternative splicing results in multiple isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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