Thermo Fisher Scientific FGFR1 Monoclonal Antibody (2C1)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGLSHH SAWLTVLEAL EERPAVMTSP LYLEIIIYCT GAFLISCMVG SVIVYKMKSG TKKSDF

Target Information

FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which serve as high-affinity receptors for 17 growth factors (FGF1–17).
The FGF receptor family plays a crucial role in various biological processes such as:

• Mesoderm induction and patterning
• Cell growth and migration
• Organ formation and bone growth

FGFR1 is alternatively spliced, generating multiple splice variants expressed differently during embryonic development and in adult tissues. Mutations or defects in FGFR1 are associated with several diseases, including:

• Pfeiffer syndrome (PS)
• Idiopathic hypogonadotropic hypogonadism (IHH)
• Kallmann syndrome type 2 (KAL2)
• Osteoglophonic dysplasia (OGD)
• Non-syndromic trigonocephaly
• Jackson-Weiss syndrome
• Antley-Bixler syndrome

Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.