Thermo Fisher Scientific FGFR1 Monoclonal Antibody (2C1)
FGFR1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 2C1). Western blot 및 ELISA에 적합하며, 인간 시료에 반응. 고순도 Affinity chromatography로 정제된 액상 형태로 제공되며, 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C1 |
| Immunogen | FGFR1 (NP_000595.1, 303–408 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGLSHH SAWLTVLEAL EERPAVMTSP LYLEIIIYCT GAFLISCMVG SVIVYKMKSG TKKSDF
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which serve as high-affinity receptors for 17 growth factors (FGF1–17).
The FGF receptor family plays a crucial role in various biological processes such as:
- Mesoderm induction and patterning
- Cell growth and migration
- Organ formation and bone growth
FGFR1 is alternatively spliced, generating multiple splice variants expressed differently during embryonic development and in adult tissues. Mutations or defects in FGFR1 are associated with several diseases, including:
- Pfeiffer syndrome (PS)
- Idiopathic hypogonadotropic hypogonadism (IHH)
- Kallmann syndrome type 2 (KAL2)
- Osteoglophonic dysplasia (OGD)
- Non-syndromic trigonocephaly
- Jackson-Weiss syndrome
- Antley-Bixler syndrome
Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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