Thermo Fisher Scientific Phospho-AMPK alpha-1,2 (Thr183, Thr172) Polyclonal Antibody
Phospho-AMPK alpha-1,2 (Thr183, Thr172) 폴리클로날 항체로 인간, 마우스, 랫트에서 반응. Western blot 및 ELISA에 적합하며, 액상 형태로 공급. AMPK 인산화 상태 연구에 유용. -20°C 보관 권장.
- 카탈로그번호
- PA5121274
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around T183 of human PRKAA1 (NP_0062425) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.48 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914846 |
Product Specific Information
- Positive test controls include: 293T, C6
- Immunogen sequence: LRTSC
Target Information
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits.
AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to metabolic stress, AMPK is activated and phosphorylates acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR), key enzymes in fatty acid and cholesterol biosynthesis regulation.
Studies in mice suggest this subunit is essential for maintaining myocardial energy homeostasis during ischemia and may influence whole-body insulin sensitivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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