Thermo Fisher Scientific CDK1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with bovine, chicken, mouse, and rat based on sequence homology.
Heat-mediated antigen retrieval is recommended prior to staining, using a 10 mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 minutes.
Following antigen retrieval, incubate samples with primary antibody for 10 minutes at room temperature.
A suggested positive control is breast carcinoma or tonsil tissue.

Target Information

CDK1 (Cell Division Control protein 1) is essential for the completion of START, the controlling event in the cell cycle required to initiate mitosis.
CDK1 acts as the catalytic subunit of the M-Phase Promoting Factor, a protein kinase complex that induces entry into mitosis and is conserved among eukaryotes.
Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays apoptosis onset.
Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.