Thermo Fisher Scientific FNTA Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–3 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

• Suggested positive control: mouse colon cell lysate.

Target Information

FNTA (Farnesyltransferase, CAAX box; alphaCAAX farnesyltransferase alpha subunit, FPTA, FTase-alpha, GGTase-I-alpha, Protein farnesyl transferase / geranyl geranyl transferase type I alpha subunit (PGGT1A), Ras proteins prenyl transferase alpha, Type I protein geranyl-geranyl transferase alpha subunit) is located at locus 8p11 (human).
Prenylation is a common intracellular posttranslational protein modification catalyzed by prenyltransferases. The best characterized among these prenyltransferases is the CAAX farnesyl transferase (2.5.1.21), which is an alpha-beta heterodimeric enzyme. It catalyzes the attachment of a farnesyl group from farnesyl phosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box.
FNTA or the alpha subunit of farnesyl transferase is shared by the geranyl-geranyl protein transferases. Apart from transfer of farnesyl and geranyl groups to proteins, FNTA has been proposed to regulate intracellular signaling pathways involving p21ras. Reports have shown that FNTA interacts with TGF-beta and activin-type I receptors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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