Thermo Fisher Scientific GBL Polyclonal Antibody
Rabbit polyclonal antibody against human LST8 (GBL protein), suitable for Western blot applications. Unconjugated form, liquid at 0.5 mg/mL concentration. Conserved across species and involved in mTOR signaling research. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 150–200 of human LST8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1074502 |
Product Specific Information
This antibody is 93% homologous to xenopus.
Target Information
G-protein beta subunit-like (GBL protein) is a novel member of the WD-40 protein family. It is a highly conserved cytosolic protein consisting of seven WD-40 repeating motifs. LST8 is a functional component of the mTOR signaling complex (TORC1) and positively regulates the mTOR pathway. It interacts with the kinase domain of mTOR and stabilizes its interaction with raptor.
LST8 participates in regulating cell growth and in nutrient and growth factor-mediated mTOR signaling to S6K1. Reports suggest up-regulated expression of LST8 due to insulin, indicating a possible role in intracellular events related to insulin-receptor activation, including insulin-stimulated glucose transport and glycogen synthesis. Northern blot analysis detected ubiquitous expression of LST8, with highest expression in brain and testis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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