Thermo Fisher Scientific ALK Monoclonal Antibody (OTI1E12), TrueMAB
ALK 단백질을 인식하는 Mouse monoclonal antibody로, Western blot 및 IHC(Paraffin)에 사용 가능. Human 시료 반응성. Lyophilized 형태로 제공되며, 재구성 후 약 1 mg/mL 농도로 사용. 뇌 발달 관련 ALK 단백질 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E12 |
| Immunogen | Full length human recombinant protein of human ALK produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is essential for brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with several tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
The most frequent alteration is chromosomal rearrangement resulting in a fusion gene combining ALK (chromosome 2) and NPM (chromosome 5), producing an oncogenic NPM-ALK fusion protein.
ALK encodes a receptor protein-tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK.
It plays a critical role in neural development and function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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