Thermo Fisher Scientific Erythropoietin (EPO) Monoclonal Antibody (EPO, 1368)
인간 EPO 단백질에 특이적인 마우스 단클론 항체로, WB, IHC(P), Peptide Array 등에 사용 가능. 단백질 A/G 정제, PBS 완충액에 보존, 보존제 무첨가. 적혈구 전구세포 분화 연구 및 EPO 관련 신호전달 연구에 적합.
- 카탈로그번호
- 2056-MSM2-P1ABX
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–4 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | EPO, 1368 |
| Immunogen | Recombinant fragment (around aa 28–162) of human EPO protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C or –80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Tested in direct ELISA (use antibody at 2–4 µg/mL for coating).
- For immunohistochemistry (PFA-fixed): incubate antibody for 30 minutes at room temperature.
- For formalin-fixed tissues: heat tissue sections in 10 mM Tris Buffer with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, then cool at room temperature for 20 minutes.
Target Information
Erythropoietin (EPO) is a growth factor essential for the survival, proliferation, and differentiation of erythroid precursors.
It induces the final maturation of partially differentiated erythroid cells and promotes production of red cell-specific proteins such as hemoglobin.
EPO receptor (EPOR) expression is highest in precursor cells and decreases as cells mature.
Hepatocytes are the main source of EPO during fetal development, while renal interstitial cells become the primary source after birth and throughout adulthood.
EPO expression increases under hypoxic conditions, and low-level expression has been observed in lung and brain tissues.
Recent studies suggest EPO may also contribute to neuronal protection and tissue repair.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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