Thermo Fisher Scientific CD6 (Negative Marker of T-regulatory Cells) Monoclonal Antibody (SPV-L14)
CD6 단백질을 표적으로 하는 Monoclonal Antibody로, T-regulatory 세포의 음성 마커로 사용됩니다. 인간 및 마우스 시료에 반응하며, ICC/IF 및 유세포분석(Flow Cytometry)에 적합합니다. 단백질 A/G로 정제된 액상 형태로, 보존제 없이 PBS(pH 7.4)에 저장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPV-L14 |
| Immunogen | CD8+ cytotoxic T-cell clone |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD6 (also known as T12) is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia (ALL) cells.
CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and acts as a coreceptor for T cell activation and a stabilizer of the immunological synapse.
CD6–ALCAM mediated cell adhesion is important for T cell proliferation, and CD6 may function via association with CD5, modulating CD5 signaling.
Ligation of CD6 has an anti-apoptotic role in chronic lymphocytic leukemia B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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