Thermo Fisher Scientific CD6 (Negative Marker of T-regulatory Cells) Monoclonal Antibody (C6/372, 3F7B5)
인간 CD6 단백질을 인식하는 mouse monoclonal antibody로, T-regulatory cell의 음성 마커로 사용됩니다. IHC 및 ICC/IF에 적합하며, 비결합형 액상 형태로 제공됩니다. Protein A/G 정제, 4°C 보관 권장.
- 카탈로그번호
- 923-MSM4-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD6 (Negative Marker of T-regulatory Cells) Monoclonal Antibody (C6/372, 3F7B5)
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Immunocytochemistry (ICC/IF)
- 2–4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C6/372, 3F7B5 |
| Immunogen | Human recombinant CD6 protein (C6/372); Human rheumatoid synovial T cell line ST-1 (3F7B5) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL).
CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse.
CD6-ALCAM mediated cell adhesion is also important for T cell proliferation.
CD6 may exert some of its functions via association with CD5, probably by fine-tuning CD5 signaling.
Ligation of CD6 has an antiapoptotic role in chronic lymphocytic leukemia B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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