Thermo Fisher Scientific GDAP1L1 Monoclonal Antibody (OTI1C3), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The ganglioside GD3 synthase induces cell differentiation with neurite sprouting when transfected into the mouse neuroblastoma cell line Neuro2a. After differentiation, expression of several genes is upregulated, including one encoding ganglioside-induced differentiation-associated protein 1 (Gdap1).
A similar gene exists in humans, and mutations in the human gene are associated with Charcot-Marie-Tooth type 4A disease. The encoded protein is similar in sequence to human GDAP1. Several transcript variants encoding different isoforms, as well as a noncoding transcript variant, have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.