Thermo Fisher Scientific MORF4 Monoclonal Antibody (OTI2E4), TrueMAB

Thermo Fisher Scientific MORF4 Monoclonal Antibody (OTI2E4), TrueMAB

Applications and Tested Dilution

• Western Blot (WB): 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

Cellular senescence is the terminal non-dividing state that normal cells enter after completing their proliferative potential. Fusions of immortal human cell lines have led to classification into four complementation groups.
Mortality factor 4 (MORF4) is the lead member of a transcription factor-like protein family that reverses the immortal phenotype. MORF4 localizes to the nucleus and contains motifs such as helix-loop-helix and leucine zipper, enabling formation of transcriptionally active homo- or heterodimers.
MORF4 binds transcription corepressors mSin3A and TLE, suggesting that these complexes may repress genes involved in cellular senescence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.