Thermo Fisher Scientific alpha Catenin Polyclonal Antibody
Thermo Fisher Scientific의 alpha Catenin Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하는 Rabbit IgG 항체입니다. WB, IHC, ICC, IP 등 다양한 응용에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 고순도(>95%)로 100 kDa 단백질을 검출합니다.
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- PA536046
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Immunoprecipitation (IP) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids at the C-terminus of human Catenin-alpha2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553342 |
Product Specific Information
- Detects endogenous alpha catenin protein at approximately 100 kDa.
- Purity: >95% by SDS-PAGE.
Target Information
Alpha catenin is a member of the β-catenin family of cytosolic proteins. It interacts with N-cadherin and β-catenin on the cytosolic side of adherens junctions to mediate the interaction with the actin cytoskeleton.
In solution, alpha catenin exists as a homodimer but dissociates to form a 1:1 heterodimer with β-catenin to interact with cadherins.
It plays a role in regulating synaptic morphological plasticity and cerebellar and hippocampal lamination during development, as well as in the control of startle modulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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