Thermo Fisher Scientific RNF111 Polyclonal Antibody
RNF111 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합. 인간, 마우스, 랫트 반응성. 고순도 Affinity chromatography 정제, 액상 형태로 -20°C 보관. 연구용 전용 제품.
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- PA5106655
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RNF111 (Accession Q6ZNA4), corresponding to amino acid residues Y907–R957 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854323 |
Product Specific Information
Antibody detects endogenous levels of total RNF111.
Target Information
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. It interacts with the transforming growth factor (TGF)-beta/NODAL signaling pathway by promoting ubiquitination and proteosomal degradation of negative regulators such as SMAD proteins, enhancing TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in mesoderm induction during embryonic development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
[provided by RefSeq, Jul 2012]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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