Thermo Fisher Scientific RFWD2 Polyclonal Antibody
RFWD2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 친화 크로마토그래피 정제, 액상 형태, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RFWD2 (Accession Q8NHY2), corresponding to amino acid residues T361–L411 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854325 |
Product Specific Information
Antibody detects endogenous levels of total RFWD2.
Target Information
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins.
E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme and transfer it to targeted substrates.
Involved in JUN ubiquitination and degradation, and directly mediates p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis.
Ubiquitinates p53 independently of MDM2 or RCHY1, and likely acts as the essential RING domain subunit of larger E3 complexes.
Also involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival.
Ubiquitinates MTA1 and CEBPA (upon TRIB1 binding).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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